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Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma

Hollmann, C. Annette and Tzankov, Alexandar and Martínez-Marignac, Verónica L. and Baker, Kristi and Grygorczyk, Czeslawa and Grygorczyk, Ryszard and Foulkes, William and Nadeau, Jay and Dirnhofer, Stephan and Aloyz, Raquel. (2010) Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma. Leukemia research, Vol. 34, no. 5. pp. 585-593.

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Official URL: http://edoc.unibas.ch/dok/A6005705

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Abstract

We report that 38% of primary large B-cell lymphoma (DLBCL) tested expressed active Src family kinases, which are targeted by dasatinib. The expression of active Src family of kinases (SFK) in primary DLBCL tumors correlated with unfavorable prognostic markers such as Ki67 and Mum1. Using four DLBCL cell lines we found that: (1) sensitivity to dasatinib (but not imatinib) varied 400-fold; (2) dasatinib resistance was associated with distinct signaling profiles downstream of BCR activation. In particular, although Src family kinase phosphorylation was inhibited by 100-150 nM dasatinib in all cell lines, this failed to inhibit BCR-mediated Blnk phosphorylation, calcium signaling and proliferation in a dasatinib resistant cell line.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
UniBasel Contributors:Dirnhofer, Stephan and Tzankov, Alexandar
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0145-2126
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:26

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