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Neural correlates of reward processing in schizophrenia--relationship to apathy and depression

Simon, Joe J. and Biller, Armin and Walther, Stephan and Roesch-Ely, Daniela and Stippich, Christoph and Weisbrod, Matthias and Kaiser, Stefan. (2010) Neural correlates of reward processing in schizophrenia--relationship to apathy and depression. Schizophrenia research, Vol. 118, H. 1-3. pp. 154-161.

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Official URL: http://edoc.unibas.ch/dok/A6005441

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Abstract

The present study employs a new framework to categorise the heterogeneous findings on the relationship between impaired reward processing and negative and affective symptoms of schizophrenia. Based on previous behavioural and neuroimaging studies we postulate that "wanting" (i.e. anticipation) of a reward is specifically related to apathy, whereas "liking" (i.e. hedonic impact) is related to anhedonia and depression--symptoms commonly observed in schizophrenia. Fifteen patients with schizophrenia or schizoaffective disorder treated with atypical antipsychotic drugs and fifteen healthy controls performed a probabilistic monetary incentive delay task while undergoing functional magnetic resonance imaging. At the group level we found no significant differences between patients and controls in neural activation during anticipation or receipt of a reward. However, in patients with schizophrenia specific relationships between ventral-striatal activation and symptoms were observed. Ventral-striatal activation during reward anticipation was negatively correlated with apathy, while activation during receipt of reward was negatively correlated with severity of depressive symptoms. These results suggest that the link between negative symptoms and reward anticipation might specifically relate to apathy, i.e. a lack of motivation and drive. Impaired hedonic reward processing might contribute to the development of depressive symptoms in patients with schizophrenia, but it is not directly associated with self-rated anhedonia. These results indicate the necessity of more specifically differentiating negative and affective symptoms in schizophrenia in order to understand the role of the reward system in their pathogenesis.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Neuroradiologie (Stippich)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Neuroradiologie (Stippich)
UniBasel Contributors:Stippich, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0920-9964
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:22

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