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GABAergic dysfunction in essential tremor : an 11C-flumazenil PET study

Boecker, Henning and Weindl, Adolf and Brooks, David J. and Ceballos-Baumann, Andres O. and Liedtke, Christoph and Miederer, Matthias and Sprenger, Till and Wagner, Klaus J. and Miederer, Isabelle. (2010) GABAergic dysfunction in essential tremor : an 11C-flumazenil PET study. Journal of nuclear medicine, Vol. 51, H. 7. pp. 1030-1035.

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Official URL: http://edoc.unibas.ch/dok/A6005307

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Abstract

Essential tremor is the most common movement disorder, but the underlying pathophysiology is not well understood. A primary overactivity of cerebellothalamic output pathways is the most conspicuous finding, as indicated by animal and human studies. It has been argued that this overactivity may be due to impaired central inhibition, and converging evidence points toward a potential role of gamma-aminobutyric acid (GABA) dysfunction in tremor generation.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Neuroimaging (Sprenger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Neuroimaging (Sprenger)
UniBasel Contributors:Sprenger, Till
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Society of nuclear medicine
ISSN:0022-3123
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:22

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