Pituitary volume increas during emerging psychosis

Büschlen, Jeannine and Berger, Gregor E. and Borgwardt, Stefan J. and Aston, Jacqueline and Gschwandtner, Ute and Pflueger, Marlon O. and Kuster, Pascal and Radü, Ernst Wilhem and Stieglitz, Rolf-Dieter and Riecher-Rössler, Anita. (2011) Pituitary volume increas during emerging psychosis. Schizophrenia Research, 125 (1). pp. 41-48.

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Official URL: http://edoc.unibas.ch/dok/A6018469

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Background: Morphologic abnormalities of the pituitary gland volume (PV) have been reported in schizophrenia, but at what point in time they occur remains unclear. This study determines PV across different stages of emerging psychotic disorders compared to healthy controls.
Methods: We compared PV of 36 individuals with an at-risk mental state (ARMS) for psychosis, 23 patients with a first episode psychosis (FEP) and 20 healthy controls (HC). Transition to psychosis was monitored using the BPRS transition criteria according to Yung et al. (Yung, A.R. et al., 1998. Prediction of psychosis. A step towards indicated prevention of schizophrenia. Br. J. Psychiatry Suppl. 172 (33), 14-20). Applying these transition criteria, 16 of the 36 ARMS individuals made the transition to psychosis (ARMS-T) and 20 did not (ARMS-NT). We traced PV manually on 1 mm slices of magnetic resonance images in three dimensions (corona], sagittal and axial) blind to group status. We used univariate analysis of covariance (ANCOVA) with PV as dependent variable, group and sex as between-subject factors and whole brain volume as covariate.
Results: PV increased from HC to ARMS-NT to ARMS-T/FEP. ANCOVA revealed a significant effect of group (F(3,78) = 3.0; p = .036) and a sex x group interaction (F(3,78) = 6.5; p = .001). Over all groups, women had considerably larger PV than men (F(1,78) = 9.8; p = .003).
Conclusions: Our findings provide further evidence that PV is increased in emerging psychotic disorders, and suggest that this is due to a stress-associated activation of the pituitary gland.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Klinische Psychologie und Psychiatrie (Stieglitz)
UniBasel Contributors:Stieglitz, Rolf Dieter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article -- The final publication ist available at Elsevier, see DOI link
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Last Modified:15 Nov 2016 12:58
Deposited On:24 May 2013 09:20

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