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Chronic impact of topiramate on acid-base balance and potassium in childhood

Belotti, Eva A. and Taddeo, Ilaria and Ragazzi, Monica and Pifferini, Rosanna and Simonetti, Giacomo D. and Bianchetti, Mario G. and Ramelli, Gian P.. (2010) Chronic impact of topiramate on acid-base balance and potassium in childhood. European journal of paediatric neurology, Vol. 14, H. 5. pp. 445-448.

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Official URL: http://edoc.unibas.ch/dok/A6006309

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Abstract

Topiramate, which is commonly prescribed for seizure disorders and migraine prophylaxis, sometimes causes metabolic acidosis and hypokalemia. Since the effects of topiramate on acid-base balance and potassium levels have not been well explored in children, acid-base balance, anion gap and potassium were assessed in 24 patients (8 females and 16 males) aged between 4.6 and 19 years on topiramate for more than 12 months and in an age-matched control group. Plasma bicarbonate (21.7 versus 23.4 mmol/L; P>0.03), carbon dioxide pressure (39.7 versus 43.2mm Hg; P>0.05), and potassium (3.7 versus 4.0 mmol/L; P>0.03) were on the average lower and chloride (109 versus 107 mmol/L; P>0.03) higher in patients treated with topiramate than in controls. Blood pH, plasma sodium and the anion gap were similar in patients on topiramate and in controls. In patients on topiramate no significant correlation was observed between the dosage of this agent and plasma bicarbonate or potassium as well as between topiramate blood level and the mentioned electrolytes. In conclusion long-term topiramate treatment is associated with a mild, statistically significant tendency towards compensated normal anion gap metabolic acidosis and hypokalemia.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
UniBasel Contributors:Ramelli, Gian Paolo
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1090-3798
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:23
Deposited On:24 May 2013 09:13

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