edoc

Outcome of patients developing GVHD after DLI given to treat CML relapse : a study by the Chronic Leukemia Working Party of the EBMT

Chalandon, Y. and Passweg, J. R. and Schmid, C. and Olavarria, E. and Dazzi, F. and Simula, M. P. and Ljungman, P. and Schattenberg, A. and de Witte, T. and Lenhoff, S. and Jacobs, P. and Volin, L. and Iacobelli, S. and Finke, J. and Niederwieser, D. and Guglielmi, C. and Chronic Leukemia Working Party of European Group for Blood, and Marrow Transplantation, . (2010) Outcome of patients developing GVHD after DLI given to treat CML relapse : a study by the Chronic Leukemia Working Party of the EBMT. Bone marrow transplantation, Vol. 45, H. 3. pp. 558-564.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6004071

Downloads: Statistics Overview

Abstract

We studied GVHD after donor lymphocyte infusion (DLI) in 328 patients with relapsed CML between 1991 and 2004 . A total of 122 patients (38%) developed some form of GVHD. We analyzed GVHD by clinical presentation (acute or chronic GVHD) and onset time after the first DLI (early (> or =45 days) or late (<45 days)). There was a significant overlap between onset time and clinical presentation. Some form of GVHD occurred at a median of 104 days, acute GVHD at 45 days and chronic GVHD at 181 days after DLI. The clinical presentation was acute GVHD in 71 patients, of whom 31 subsequently developed chronic GVHD subsequently. De novo chronic GVHD was seen in 51 patients. OS for all patients was 69% (95% confidence interval (CI) 63-75) at 5 years, DLI-related mortality was 11% (95% CI 8-15) and disease-related mortality was 20% (95% CI 16-25). Risk factors for developing GVHD after DLI were T-cell dose at first DLI, the time interval from transplant to DLI and donor type. In time-dependent multivariate analysis, GVHD after DLI was associated with a risk of death of 2.3-fold compared with patients without GVHD. Clinical presentation as acute GVHD and early onset GVHD were associated with increased mortality.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
UniBasel Contributors:Passweg, Jakob R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:0268-3369
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:12

Repository Staff Only: item control page