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Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma

Smida, Jan and Baumhoer, Daniel and Rosemann, Michael and Walch, Axel and Bielack, Stefan and Poremba, Christopher and Remberger, Klaus and Korsching, Eberhard and Scheurlen, Wolfram and Dierkes, Christian and Burdach, Stefan and Jundt, Gernot and Atkinson, Michael J. and Nathrath, Michaela. (2010) Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. Clinical cancer research, Vol. 16, no. 16. pp. 4256-4267.

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Official URL: http://edoc.unibas.ch/dok/A6005201

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Abstract

Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establish molecular prognostic markers at the time of diagnosis, the most accepted predictive factor remains the histologic evaluation of necrosis after neoadjuvant chemotherapy. The present approach was carried out to search for genome-wide recurrent loss of heterozygosity and copy number variations that could have prognostic and therapeutic impact for osteosarcoma patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Jundt, Gernot
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for Cancer Research
ISSN:1078-0432
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:06

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