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Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure : a genome-wide association study

Rauch, Andri and Kutalik, Zoltán and Descombes, Patrick and Cai, Tao and Di Iulio, Julia and Mueller, Tobias and Bochud, Murielle and Battegay, Manuel and Bernasconi, Enos and Borovicka, Jan and Colombo, Sara and Cerny, Andreas and Dufour, Jean-François and Furrer, Hansjakob and Günthard Huldrych, F. and Heim, Markus and Hirschel, Bernard and Malinverni, Raffaele and Moradpour, Darius and Müllhaupt, Beat and Witteck, Andrea and Beckmann, Jacques S. and Berg, Thomas and Bergmann, Sven and Negro, Francesco and Telenti, Amalio and Bochud, Pierre-Yves and Swiss Hepatitis C. Cohort Study, and Swiss HIV Cohort Study, . (2010) Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure : a genome-wide association study. Gastroenterology, Vol. 138, H. 4 , S. 1338-1345, 1345.e1-7.

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Official URL: http://edoc.unibas.ch/dok/A6005003

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Abstract

Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)
UniBasel Contributors:Battegay, Manuel E. and Hirsch, Hans H. and Heim, Markus H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Saunders
ISSN:0016-5085
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:05

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