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Truncated militarinone fragments identified by total chemical synthesis induce neurite outgrowth

Schmid, Fabian and Jessen, Henning J. and Burch, Patrick and Gademann, Karl. (2013) Truncated militarinone fragments identified by total chemical synthesis induce neurite outgrowth. MedChemComm , 4 (1). pp. 135-139.

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Official URL: http://edoc.unibas.ch/dok/A6083533

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Abstract

A group of natural products produced by entomopathogenic fungi has recently been shown to induce neurite outgrowth in the absence of nerve growth factor (NGF) in pheochromocytoma PC-12 cell culture. After completion of a total synthesis program, we continued our efforts in reducing complexity by synthetically preparing truncated analogs. Using this approach we were able to not only significantly simplify the structures but also decrease the minimum concentration needed for neuritogenic activity by a factor of 20. This activity was suppressed in the presence of an ERK1/2 inhibitor suggesting activation of the mitogen activated protein kinase (MAPK) pathway as a potential mode of action of these pyridone alkaloids.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann)
UniBasel Contributors:Schmid, Fabian and Jessen, Henning and Burch, Patrick and Gademann, Karl
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:2040-2503
e-ISSN:2040-2511
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:16 Feb 2017 11:17
Deposited On:24 May 2013 09:05

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