Beeinflussung von Netzhautdickenwerten durch antiangiogenetische Therapie bei altersbedingter Makuladegeneration

Golbaz, I. and Ahlers, C. and Schütze, C. and Stock, G. and Mylonas, G. and Prünte, C. and Schmidt-Erfurth, U.. (2009) Beeinflussung von Netzhautdickenwerten durch antiangiogenetische Therapie bei altersbedingter Makuladegeneration. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, Vol. 106. pp. 1103-1110.

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Official URL: http://edoc.unibas.ch/dok/A6006935

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BACKGROUND: This study evaluated the impact of antiangiogenetic therapy on differences in central retinal thickness (CRT) as measured with two optical coherence tomography (OCT) systems from the same manufacturer. MATERIAL AND METHODS: Data were obtained from a group of 20 patients with neovascular age-related macular degeneration before and after intravitreal treatment with ranibizumab. Imaging was performed using the Stratus and the high-definition (HD) Cirrus OCT systems. RESULTS: The mean CRT was revealed to be significantly lower as measured by OCT compared with HD-OCT before and after treatment (p>0.002). CRT differences varied more strongly before treatment than after treatment. A higher standard deviation was noted before treatment. The difference in the mean deviation of CRT measurements before and following antiangiogenetic therapy was highly significant. CONCLUSION: This study showed that differences in CRT measurements between different OCT systems were subject not only to technical differences but also to treatment effects of current antiangiogenetic strategies. These effects should be recognized because clinical studies increasingly define OCT parameters as primary or secondary outcome measures.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ophthalmologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ophthalmologie USB
UniBasel Contributors:Prünte, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Note:Note: Englischer Titel: Influence of antiangiogenetic therapy on retinal thickness values in age-related macular degeneration -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:02

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