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The Prospective Oral Mucositis Audit : relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT

McCann, S. and Schwenkglenks, M. and Bacon, P. and Einsele, H. and D'Addio, A. and Maertens, J. and Niederwieser, D. and Rabitsch, W. and Roosaar, A. and Ruutu, T. and Schouten, H. and Stone, R. and Vorkurka, S. and Quinn, B. and Blijlevens, N. and Ebmt Mucositis Advisory Group, . (2009) The Prospective Oral Mucositis Audit : relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT. Bone marrow transplantation, Vol. 43. pp. 141-147.

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Official URL: http://edoc.unibas.ch/dok/A6007037

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Abstract

The Prospective Oral Mucositis Audit was an observational study in 197 patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) undergoing, respectively, high-dose melphalan or BEAM chemotherapy and autologous SCT at 25 European centres. We evaluated the relationship between severe oral mucositis (SOM; WHO Oral Toxicity Scale grade 3-4) and local and systemic clinical sequelae and medical resource use. SOM occurred in 44% of patients. The duration of SOM (mean 5.3 days) correlated with time to neutrophil engraftment. The following parameters increased gradiently with maximum grade of oral mucositis: duration of pain score <or=4, opioid use, dysphagia score <or=4, total parenteral nutrition (TPN) use, incidence and/or duration of fever and infection, and duration of antibiotic use. SOM increased the duration of TPN use by 2.7 days (P>0.001), opioids by 4.6 days (P>0.001), and antibiotics by 2.4 days (P=0.045). SOM prolonged hospital stay by 2.3 days (P=0.013) in MM patients, but not in NHL patients (who tended to have a longer hospital stay). In conclusion, this analysis of prospectively collected observational data provides important insight into the scope and impact of SOM in the European transplant setting.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Schwenkglenks, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:0268-3369
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:10 Oct 2014 09:19
Deposited On:24 May 2013 09:02

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