Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma

Luu, Van-Duc and Boysen, Gunther and Struckmann, Kirsten and Casagrande, Silvia and von Teichman, Adriana and Wild, Peter J. and Sulser, Tullio and Schraml, Peter and Moch, Holger. (2009) Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clinical cancer research : a journal of clinical and translational research, Vol. 15. pp. 3297-3304.

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Official URL: http://edoc.unibas.ch/dok/A6004265

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The paired box gene 2, PAX2, encodes for a transcription factor that is up-regulated during nephrogenesis and becomes silenced in mature epithelium of the glomeruli, the proximal, and distal tubules. Reactivation of PAX2 has been frequently observed in clear cell renal cell carcinoma (ccRCC), a tumor type characterized by loss of von Hippel-Lindau (VHL) tumor suppressor function. The regulation of PAX2 expression in ccRCC is unknown.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Schraml, Peter Hans
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for Cancer Research
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:21
Deposited On:24 May 2013 09:00

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