edoc

Thresholds for therapies : highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009

Goldhirsch, A. and Ingle, J. N. and Gelber, R. D. and Coates, A. S. and Thürlimann, B. and Senn, H.-J.. (2009) Thresholds for therapies : highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Annals of oncology : official journal of the European Society for Medical Oncology, Vol. 20. pp. 1319-1329.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6002959

Downloads: Statistics Overview

Abstract

The 11(th) St Gallen (Switzerland) expert consensus meeting on the primary treatment of early breast cancer in March 2009 maintained an emphasis on targeting adjuvant systemic therapies according to subgroups defined by predictive markers. Any positive level of estrogen receptor (ER) expression is considered sufficient to justify the use of endocrine adjuvant therapy in almost all patients. Overexpression or amplification of HER2 by standard criteria is an indication for anti-HER2 therapy for all but the very lowest risk invasive tumours. The corollary is that ER and HER2 must be reliably and accurately measured. Indications for cytotoxic adjuvant therapy were refined, acknowledging the role of risk factors with the caveat that risk per se is not a target. Proliferation markers, including those identified in multigene array analyses, were recognised as important in this regard. The threshold for indication of each systemic treatment modality thus depends on different criteria which have been separately listed to clarify the therapeutic decision-making algorithm.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Onkologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Onkologie
UniBasel Contributors:Thürlimann, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0923-7534
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:24 May 2013 09:21
Deposited On:24 May 2013 09:00

Repository Staff Only: item control page