Biodegradable polymer-lipid monolayers as templates for calcium phosphate mineralization

Jagoda, Agnieszka and Zinn, Manfred and Bieler, Eva and Meier, Wolfgang and Kita-Tokarczyk, Katarzyna. (2013) Biodegradable polymer-lipid monolayers as templates for calcium phosphate mineralization. Journal of Materials Chemistry B, 1 (3). pp. 368-378.

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Official URL: http://edoc.unibas.ch/dok/A6070518

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A combination of poly([R]-3-hydroxy-10-undecenoate) (PHUE), a biodegradable polymer from the group of polyhydroxyalkanoates (PHAs), and lipids of different head groups was used to support the growth of calcium phosphate, the main component of mammalian bones. Crystallization took place under two-dimensional films (Langmuir monolayers). The addition of a negatively charged lipid, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine, to a PHUE film led to the formation of lipid domains (rich in negative charge), and resulted in excellent mineralization control: crystals with uniform size and morphology were formed. The results show that carefully optimized combinations of materials can lead to better control of calcium phosphate crystallization compared to one-component organic scaffolds.
Faculties and Departments:01 Faculty of Theology > Fachbereich Theologie > Praktische Theologie (Bieler)
05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:04 Jun 2018 12:20
Deposited On:24 May 2013 08:58

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