Chemically Programmed Supramolecular Assembly of Hemoprotein and Streptavidin with Alternating Alignment

Oohora, Koji and Burazerovic, Sabina and Onoda, Akira and Wilson, Yvonne M. and Ward, Thomas R. and Hayashi, Takashi. (2012) Chemically Programmed Supramolecular Assembly of Hemoprotein and Streptavidin with Alternating Alignment. Angewandte Chemie International Edition, 51 (16). pp. 3818-3821.

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Official URL: http://edoc.unibas.ch/dok/A6070736

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It is shown that an intramolecularly linked cofactor dyad enforces the assocn. of two different proteins according to a predefined program.  The present study demonstrates that the heme-bis(biotin) conjugate contains the information to produce a stable 2:1 Mb-SAv complex.  Propagation of this moiety into a polymer results from using a dimericMb building block.  The supramol. composite fiber obsd. by AFM techniques is the first example of a chem. programmed heterotropic protein copolymer with alternating alignment.  The heme cofactor's dioxygen binding function is maintained upon incorporation within the fiber, suggesting that this approach is well-suited for the creation of functional nanobiomaterials.  Immobilization of the first building block will allow to: (1) study the programmed assembly by quartz microbalance anal., (2) increase the complexity by varying the capping groups on the dyad and/or (3) introduce addnl. protein building blocks to afford protein polymers with a desired sequence and function.  Potential applications include multifunctional catalysis, artificial photosynthesis, and smart nanomaterials for medical applications.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Wilson, Yvonne Martha and Ward, Thomas R. R.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Apr 2017 10:07
Deposited On:24 May 2013 08:58

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