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Identification of two-histidines one-carboxylate binding motifs in proteins amenable to facial coordination to metals

Amrein, Beat and Schmid, Maurus and Collet, Guillaume and Cuniasse, Philippe and Gilardoni, Francois and Seebeck, Florian P. and Ward, Thomas R.. (2012) Identification of two-histidines one-carboxylate binding motifs in proteins amenable to facial coordination to metals. Metallomics, 4 (4). pp. 379-388.

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Official URL: http://edoc.unibas.ch/dok/A6070741

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Abstract

Among natural metalloenzymes, the facial two-histidines one-carboxylate binding motif (FTM) is a widely represented first coordination sphere motif present in the active site of a variety of metalloenzymes. A PDB search revealed a total of 1685 structures bearing such FTMs bound to a metal. Sixty statistically representative FTMs were selected and used as template for the identification of structurally characterized proteins bearing these three amino acids in a propitious environment for binding to a transition metal. This geometrical superposition search, carried out using the STAMPS software, returned 2320 hits. While most consisted of either apo-FTMs or bore strong sequence homology to known FTMs, seven such structures lying within a cavity were identified as novel and viable scaffolds for the creation of artificial metalloenzymes bearing an FTM.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R. and Schmid, Maurus and Seebeck, Florian Peter and Amrein, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1756-5901
e-ISSN:1756-591X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 May 2017 09:13
Deposited On:24 May 2013 08:58

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