mTORC2 Caught in a SINful Akt

Polak, P. and Hall, M. N.. (2006) mTORC2 Caught in a SINful Akt. Developmental cell, Vol. 11, H. 4. pp. 433-434.

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Official URL: http://edoc.unibas.ch/dok/A5258141

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The target of rapamycin (TOR), a central controller of cell growth, is found in two distinct, highly conserved multiprotein complexes. Three recent papers in Cell (Jacinto et al., 2006), Developmental Cell (shiota et al., 2006; this issue), and Current Biology (Frias et al., 2006) shed light on mTOR complex 2 (mTORC2) composition and in vivo function. An important new finding is that mTORC2 determines Akt/PKB substrate specificity rather than absolute activity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:09
Deposited On:22 Mar 2012 13:19

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