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Clinical application of sensitive cardiac troponin assays : potential and limitations

Twerenbold, Raphael and Reichlin, Tobias and Mueller, Christian. (2010) Clinical application of sensitive cardiac troponin assays : potential and limitations. Biomarkers in medicine, Vol. 4, H. 3. pp. 395-401.

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Official URL: http://edoc.unibas.ch/dok/A5843847

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Abstract

Acute myocardial infarction (AMI) is the major cause of death worldwide. Cardiac troponins (cTns) are structural proteins, unique to the heart, that currently form the cornerstone of the AMI diagnosis. The major limitation of standard cTn assays is a sensitivity deficit at presentation caused by a delayed increase of circulating levels. Recent multicenter studies have demonstrated that novel, more sensitive and precise cTn assays improve the early diagnosis of AMI. cTn has to be interpreted as a quantitative variable. The term 'troponin positive' should, therefore, be avoided. 'Detectable' levels will become the norm and have to be clearly differentiated from 'elevated' levels. The differential diagnosis of a small amount of myocardial injury and, therefore, mild elevation of cTn is broad, and includes acute and chronic disorders. The differential diagnosis of a large amount of myocardial injury and, therefore, substantial elevation of cTn is much smaller and largely restricted to AMI, myocarditis and takotsubo cardiomyopathy. The aim of this article is to guide clinicians in the use of sensitive cTn.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
UniBasel Contributors:Reichlin, Tobias
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Future Medicine
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Apr 2013 07:03
Deposited On:26 Apr 2013 07:02

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