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Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts : clues towards a rational vaccination strategy

Fritz, Stefanie and Mossdorf, Erik and Durovic, Bojana and Zenhaeusern, Gabriela and Conen, Anna and Steffen, Ingrid and Battegay, Manuel and Nüesch, Reto and Hess, Christoph. (2010) Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts : clues towards a rational vaccination strategy. AIDS, Vol. 24, H. 14. pp. 2287-2289.

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Official URL: http://edoc.unibas.ch/dok/A6006766

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Abstract

In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4 T-cell counts less than 350 microl were distinct from HIV-infected individuals with more than 350 CD4 T-cell counts/microl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-gamma-secreting CD4 T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immunobiology (Hess C)
03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ophthalmologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ophthalmologie USB
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Battegay, Manuel E. and Nüesch, Reto and Hess, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Current Science
ISSN:0269-9370
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:14
Deposited On:26 Apr 2013 07:02

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