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An exploration of cognitive subgroups in Alzheimer's disease

Davidson, Julie E. and Irizarry, Michael C. and Bray, Bethany C. and Wetten, Sally and Galwey, Nicholas and Gibson, Rachel and Borrie, Michael and Delisle, Richard and Feldman, Howard H. and Hsiung, Ging-Yuek and Fornazzari, Luis and Gauthier, Serge and Guzman, Danilo and Loy-English, Inge and Keren, Ron and Kertesz, Andrew and George-Hyslop, Peter St and Wherrett, John and Monsch, Andreas U.. (2010) An exploration of cognitive subgroups in Alzheimer's disease. Journal of the International Neuropsychological Society, Vol. 16, H. 2. pp. 233-243.

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Official URL: http://edoc.unibas.ch/dok/A6004806

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Abstract

Heterogeneity is observed in the patterns of cognition in Alzheimer's disease (AD). Such heterogeneity might suggest the involvement of different etiological pathways or different host responses to pathology. A total of 627 subjects with mild/moderate AD underwent cognitive assessment with the Mini-Mental State Examination (MMSE) and the Dementia Rating Scale-2 (DRS-2). Latent class analysis (LCA) was performed on cognition subscale data to identify and characterize cognitive subgroups. Clinical, demographic, and genetic factors were explored for association with class membership. LCA suggested the existence of four subgroups; one group with mild and another with severe global impairment across the cognitive domains, one group with primary impairments in attention and construction, and another group with primary deficits in memory and orientation. Education, disease duration, age, Apolipoprotein E-epsilon4 (APOE epsilon4) status, gender, presence of grasp reflex, white matter changes, and early or prominent visuospatial impairment were all associated with class membership. Our results support the existence of heterogeneity in patterns of cognitive impairment in AD. Our observation of classes characterized by predominant deficits in attention/construction and memory respectively deserves further exploration as does the association between membership in the attention/construction class and APOE epsilon4 negative status.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie
07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Monsch, Andreas U
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cambridge University Press
ISSN:1355-6177
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 May 2013 09:13
Deposited On:26 Apr 2013 07:01

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