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Trastuzumab beyond progression: a cost-utility analysis

Matter-Walstra, K. W. and Dedes, K. J. and Schwenkglenks, M. and Brauchli, P. and Szucs, T. D. and Pestalozzi, B. C.. (2010) Trastuzumab beyond progression: a cost-utility analysis. Annals of Oncology, 21 (11). pp. 2161-2168.

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Official URL: http://edoc.unibas.ch/dok/A5844561

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Abstract

The continuation of trastuzumab beyond progression in combination with capecitabine as secondary chemotherapy for HER2-positive metastatic breast cancer (MBC) prolongs progression-free survival without a substantial increase in toxicity. A Markov cohort simulation was used to follow the clinical course of typical patients with MBC. Information on response rates and major adverse effects was derived, and transition probabilities were estimated, based on the results of the Breast International Group 03-05 clinical trial. Direct costs were assessed from the perspective of the Swiss health care system.; The addition of trastuzumab to capecitabine is estimated to cost on average an additional of ?33,980 and to yield a gain of 0.35 quality-adjusted life years (QALYs), resulting in an incremental cost-effectiveness ratio of ?98,329/QALYs gained. Probabilistic sensitivity analysis showed that the willingness-to-pay threshold of ?60,000/QALY was reached in 12% of cases.; The addition of trastuzumab to capecitabine in MBC patients is more expensive than what is typically regarded as cost-effective but falls within the value ranges found for established regimens in the treatment of MBC.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Matter-Walstra, Klazien Wietske and Schwenkglenks, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0923-7534
e-ISSN:1569-8041
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jan 2018 12:55
Deposited On:26 Apr 2013 07:01

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