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PI3Ks-drug targets in inflammation and cancer

Wymann, Matthias. (2012) PI3Ks-drug targets in inflammation and cancer. Subcellular biochemistry, Vol. 58. pp. 111-181.

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Official URL: http://edoc.unibas.ch/dok/A6005996

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Abstract

Phosphoinositide 3-kinases (PI3Ks) control cell growth, proliferation, cell survival, metabolic activity, vesicular trafficking, degranulation, and migration. Through these processes, PI3Ks modulate vital physiology. When over-activated in disease, PI3K promotes tumor growth, angiogenesis, metastasis or excessive immune cell activation in inflammation, allergy and autoimmunity. This chapter will introduce molecular activation and signaling of PI3Ks, and connections to target of rapamycin (TOR) and PI3K-related protein kinases (PIKKs). The focus will be on class I PI3Ks, and extend into current developments to exploit mechanistic knowledge for therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Cancer- and Immunobiology (Wymann)
UniBasel Contributors:Wymann, Matthias P.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0306-0225
Note:Also published in: Phosphoinositides I: Enzymes of Synthesis and Degradation. - Dordrecht : Springer, 2012. - S. 111-181 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:26 Apr 2013 07:01

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