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Fingolimod for multiple sclerosis : mechanism of action, clinical outcomes, and future directions

Mehling, Matthias and Kappos, Ludwig and Derfuss, Tobias. (2011) Fingolimod for multiple sclerosis : mechanism of action, clinical outcomes, and future directions. Current neurology and neuroscience reports, Vol. 11, no. 5. pp. 492-797.

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Official URL: http://edoc.unibas.ch/dok/A6007321

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Abstract

The oral sphingosine 1-phosphate receptor (S1PR) modulator fingolimod functionally antagonizes S1PR hereby blocking lymphocyte egress from secondary lymphoid organs to the peripheral blood circulation. This results in a reduction in peripheral lymphocyte counts, including potentially encephalitogenic T cells. In patients with relapsing multiple sclerosis fingolimod has been shown to be an effective treatment. In phase 2 and phase 3 studies fingolimod-treated patients had reduced disease activity clinically and in MRI. Although severe infectious complications occurred in single cases treated with fingolimod, the frequency of overall infections was comparable in fingolimod-treated patients and controls. Overall, in clinical studies fingolimod was well tolerated and had a favorable safety profile. In follow-up studies with continuous fingolimod, treatment showed sustained efficacy while being well tolerated.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
UniBasel Contributors:Kappos, Ludwig and Derfuss, Tobias Johannes
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Current Science Inc.
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:26 Apr 2013 07:03
Deposited On:26 Apr 2013 07:01

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