Temporal complexity in clinical manifestations of lung disease

Frey, Urs and Maksym, Geoffrey and Suki, Béla. (2011) Temporal complexity in clinical manifestations of lung disease. Journal of applied physiology, Vol. 110, no. 6. pp. 1723-1731.

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Official URL: http://edoc.unibas.ch/dok/A6007315

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In this review, we summarize results of recent research on the temporal variability of lung function, symptoms, and inflammatory biomarkers. Specifically, we demonstrate how fluctuation analysis borrowed from statistical physics can be used to gain insight into neurorespiratory control and complex chronic dynamic diseases such as asthma viewed as a system of interacting components (e.g., inflammatory, immunological, and mechanical). Fluctuation analysis tools are based on quantifying the distribution and the short- and long-term temporal history of tidal breathing and lung function parameters to assess neurorespiratory control and monitor chronic disease. The latter includes the assessment of severity and disease control, the impact of treatment and environmental triggers, the temporal characterization of disease phenotypes, and the individual risk of exacerbation. While in many cases specific mechanistic insight into the fluctuations still awaits further research, appropriate analyses of the fluctuations already impact on clinical science and practice.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
UniBasel Contributors:Frey, Urs Peter
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:American Physiological Society
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:24 May 2013 09:14
Deposited On:26 Apr 2013 07:00

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