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HIV-1 reverse transcriptase connection domain mutations : dynamics of emergence and implications for success of combination antiretroviral therapy

von Wyl, Viktor and Ehteshami, Maryam and Demeter, Lisa M. and Bürgisser, Philippe and Nijhuis, Monique and Symons, Jori and Yerly, Sabine and Böni, Jürg and Klimkait, Thomas and Schuurman, Rob and Ledergerber, Bruno and Götte, Matthias and Günthard Huldrych, F. and Swiss HIV Cohort Study, . (2010) HIV-1 reverse transcriptase connection domain mutations : dynamics of emergence and implications for success of combination antiretroviral therapy. Clinical infectious diseases, Vol. 51, H. 5. pp. 620-628.

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Official URL: http://edoc.unibas.ch/dok/A6004446

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Abstract

Factors promoting the emergence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) connection domain mutations and their effect on antiretroviral therapy (ART) are still largely undetermined. We investigated this matter by analyzing genotypic resistance tests covering 400 amino acid positions in the RT of HIV-1 subtype B viruses and corresponding treatment histories and laboratory measurements.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait)
UniBasel Contributors:Klimkait, Thomas and Hirsch, Hans H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:1058-4838
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:13
Deposited On:26 Apr 2013 06:55

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