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Neurolysis using a carbohydrate polymer gel for the treatment of postoperative neuropathic pain

Espinoza, Daniel P. and Kalbermatten, Daniel F. and Egloff, Daniel V. and Raffoul, Wassim. (2010) Neurolysis using a carbohydrate polymer gel for the treatment of postoperative neuropathic pain. Journal of plastic surgery and hand surgery, Vol. 44, H. 1. pp. 12-16.

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Official URL: http://edoc.unibas.ch/dok/A6005094

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Abstract

Perineural and intraneural fibrosis is thought to be the main cause of failure of the many surgical treatments of neuropathic pain. We have used Adcon-T/N carbohydrate polymer gel for prevention of perineural fibrosis in several parts of the body. In this retrospective study, 54 patients who presented with postoperative neuropathic pain had microsurgical epineural neurolysis and relocation of a terminal neuroma. In 19 of them, the carbohydrate gel was applied at the same time. The mean follow-up was four years and the nerve distribution varied. Postoperative improvement in pain scores (visual analogue scale (VAS) and neuropathic pain scale inventory (NPSI)), sensitivity, overall improvement and satisfaction were equivalent in the two groups, with pain relief in about 80% of the patients. There was no significant beneficial effect in the carbohydrate gel group. Patients treated with this device had a higher infection rate (21 compared with 0, p = 0.01) and delayed wound healing (31.6 compared with 11.8, p = 0.2). We conclude that good long-term pain relief is obtained postoperatively independently of the addition of carbohydrate gel. There was a slight but not significant trend towards profound pain relief with the gel.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument
UniBasel Contributors:Kalbermatten, Daniel F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Informa
ISSN:2000-656X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Apr 2013 07:02
Deposited On:26 Apr 2013 06:54

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