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Type 2 diabetes as an inflammatory disease

Donath, M. Y. and Shoelson, S. E.. (2011) Type 2 diabetes as an inflammatory disease. Nature reviews. Immunology, Vol. 11, H. 2. pp. 98-107.

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Official URL: http://edoc.unibas.ch/dok/A6007292

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Abstract

Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the vasculature and circulating leukocytes. These immunological changes include altered levels of specific cytokines and chemokines, changes in the number and activation state of various leukocyte populations and increased apoptosis and tissue fibrosis. Together, these changes suggest that inflammation participates in the pathogenesis of T2D. Preliminary results from clinical trials with salicylates and interleukin-1 antagonists support this notion and have opened the door for immunomodulatory strategies for the treatment of T2D that simultaneously lower blood glucose levels and potentially reduce the severity and prevalence of the associated complications of this disease.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Diabetes Research (Donath)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1474-1733
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:10 Apr 2015 09:13
Deposited On:26 Apr 2013 06:52

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