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Loss of hypocretin (orexin) neurons with traumatic brain injury

Baumann, Christian R. and Bassetti, Claudio L. and Valko, Philipp O. and Haybaeck, Johannes and Keller, Morten and Clark, Erika and Stocker, Reto and Tolnay, Markus and Scammell, Thomas E.. (2009) Loss of hypocretin (orexin) neurons with traumatic brain injury. Annals of neurology : official journal of the American Neurological Association and the Child Neurology Society, Vol. 66. pp. 555-559.

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Official URL: http://edoc.unibas.ch/dok/A6006775

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Abstract

Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the hypothalamic neurons that produce the wake-promoting neuropeptide hypocretin (orexin) causes the severe sleepiness of narcolepsy, and partial loss of these cells may contribute to the sleepiness of Parkinson disease and other disorders. We have found that the number of hypocretin neurons is significantly reduced in patients with severe TBI. This observation highlights the often overlooked hypothalamic injury in TBI and provides new insights into the causes of chronic sleepiness in patients with TBI.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Allgemeine Pathologie (Tolnay)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Allgemeine Pathologie (Tolnay)
UniBasel Contributors:Tolnay, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:0364-5134
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:14
Deposited On:01 Mar 2013 11:13

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