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Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats

Lebrecht, Dirk and Venhoff, Ana C. and Kirschner, Janbernd and Wiech, Thorsten and Venhoff, Nils and Walker, Ulrich A.. (2009) Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats. JAIDS : journal of acquired immune deficiency syndromes : official publication of the International Retrovirology Association, Vol. 51. pp. 258-263.

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Official URL: http://edoc.unibas.ch/dok/A6005850

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Abstract

Tenofovir disoproxil fumarate (tenofovir DF) use has been associated with renal dysfunction and Fanconi syndrome. Tenofovir is taken up into renal tubules by anion transporters where high intracellular drug concentration may induce a functionally relevant depletion of mitochondrial DNA (mtDNA). We investigated if tenofovir may induce renal mtDNA depletion and respiratory chain dysfunction.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Rheumatologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Rheumatologie
UniBasel Contributors:Walker, Ulrich A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:1525-4135
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:14
Deposited On:01 Mar 2013 11:13

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