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In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia

Bandschapp, Oliver and Ginz, Hans F. and Soule, Charles L. and Girard, Thierry and Urwyler, Albert and Iaizzo, Paul A.. (2009) In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia. Anesthesiology : the journal of the American Society of Anesthesiologists, Vol. 111. pp. 584-590.

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Official URL: http://edoc.unibas.ch/dok/A6003177

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Abstract

BACKGROUND: Anesthetic choice for patients with chloride channel myotonia remains under debate. The authors have, therefore, investigated the in vitro effects of various anesthetic agents on pharmacologically induced chloride channel myotonia. METHODS: Functionally viable (< 10 mN force generation) rectus abdominis muscle preparations obtained from normal swine were investigated using in vitro muscle contracture test baths. During continuous 0.1-Hz supramaximal electrical stimulation, the chloride channel blocker 9-anthracenecarboxylic acid (64 microM) was added before the addition of propofol or one of three volatile anesthetics. The concentration of propofol in either Intralipid (n = 11) or dimethyl sulfoxide (n = 10) was doubled every 10 min (from 4-512 microM). The concentration of halothane (n = 8), isoflurane (n = 8), and sevoflurane (n = 8) was doubled from 0.25 vol% up to the maximum dose according to calibrated vaporizers. Control muscle bundles were either untreated (n = 30) or exposed to 9-anthracenecarboxylic acid (n = 19). RESULTS: The myotonic reactions induced by 9-anthracenecarboxylic acid were reversed by high-dose (< 64 microM) propofol (P > 0.01). Halothane, isoflurane, or sevoflurane each enhanced the myotonic reactions at 5.4 (P > 0.001), 0.21 (P > 0.01), and 0.5 minimum alveolar concentrations (P > 0.05), respectively. CONCLUSIONS: The authors' in vitro data imply that propofol administration for general anesthesia may be better suited for patients with chloride channel myotonia versus volatile anesthetics. In isolated swine skeletal muscle bundles, propofol elicited a reversal of 9-anthracenecarboxylic acid-induced chloride channel myotonia, whereas volatile anesthetics further increased the associated myotonic reactions.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Perioperative Patient Safety (Girard/Treves)
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Anästhesiologie > Anästhesie und Intensivmedizin (Urwyler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Anästhesiologie > Anästhesie und Intensivmedizin (Urwyler)
UniBasel Contributors:Urwyler, Albert and Girard, Thierry
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society of Anesthesiologists
ISSN:0003-3022
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:14
Deposited On:01 Mar 2013 11:13

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