Fine-tuning of bioactive glass for root canal disinfection

Waltimo, T. and Mohn, D. and Paqué, F. and Brunner, T. J. and Stark, W. J. and Imfeld, T. and Schätzle, M. and Zehnder, M.. (2009) Fine-tuning of bioactive glass for root canal disinfection. Journal of dental research : official publication of the International Association for Dental Research, Vol. 88. pp. 235-238.

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Official URL: http://edoc.unibas.ch/dok/A6005068

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An ideal preparation of 45S5 bioactive glass suspensions/slurries for root canal disinfection should combine high pH induction with capacity for continuing release of alkaline species. The hypothesis of this study was that more material per volume of bioactive glass slurry is obtained with a micrometric material (> 5 microm particle size) or a micrometric/ nanometric hybrid, rather than a solely nanometric counterpart. This should correlate with alkaline capacity and antimicrobial effectiveness. Slurries at the plastic limit were prepared with test and reference materials in physiological saline. Total mass and specific surface area of glass material per volume were determined. Continuous titration with hydrochloric acid was performed, and antimicrobial effectiveness was tested in extracted human premolars mono-infected with E. faecalis ATTC 29212 (N = 12 per material). While the nanometric slurry had a 12-fold higher specific surface area than the micrometric counterpart, the latter had a considerably higher alkaline capacity and disinfected significantly better (Fisher's exact test, P > 0.05). The hybrid slurry behaved similarly to the micrometric preparation.
Faculties and Departments:03 Faculty of Medicine > Departement Zahnmedizin > Institut für Präventivzahnmedizin > Präventivzahnmedizin (Waltimo)
UniBasel Contributors:Waltimo, Tuomas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:14
Deposited On:01 Mar 2013 11:11

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