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Abnormal connectivity of the sensorimotor network in patients with MS : a multicenter fMRI study

Rocca, Maria A. and Absinta, Martina and Valsasina, Paola and Ciccarelli, Olga and Marino, Silvia and Rovira, Alex and Gass, Achim and Wegner, Christiane and Enzinger, Christian and Korteweg, Tjimen and Sormani, Maria Pia and Mancini, Laura and Thompson, Alan J. and De Stefano, Nicola and Montalban, Xavier and Hirsch, Jochen and Kappos, Ludwig and Ropele, Stephan and Palace, Jacqueline and Barkhof, Frederik and Matthews, Paul M. and Filippi, Massimo. (2009) Abnormal connectivity of the sensorimotor network in patients with MS : a multicenter fMRI study. Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging, Vol. 30. pp. 2412-2425.

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Official URL: http://edoc.unibas.ch/dok/A6006164

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Abstract

In this multicenter study, we used dynamic causal modeling to characterize the abnormalities of effective connectivity of the sensorimotor network in 61 patients with multiple sclerosis (MS) compared with 74 age-matched healthy subjects. We also investigated the correlation of such abnormalities with findings derived from structural MRI. In a subgroup of subjects, diffusion tensor (DT) MRI metrics of the corpus callosum and the left corticospinal tract (CST) were also assessed. MS patients showed increased effective connectivity relative to controls between: (a) the left primary SMC and the left dorsal premotor cortex (PMd), (b) the left PMd and the supplementary motor areas (SMA), (c) the left secondary sensorimotor cortex (SII) and the SMA, (d) the right SII and the SMA, (e) the left SII and the right SII, and (f) the right SMC and the SMA. MS patients had relatively reduced effective connectivity between the left SMC and the right cerebellum. No interaction was found between disease group and center. Coefficients of altered connectivity were weakly correlated with brain T2 LV, but moderately correlated with DT MRI-measured damage of the left CST. In conclusion, large multicenter fMRI studies of effective connectivity changes in diseased people are feasible and can facilitate studies with sample size large enough for robust outcomes. Increased effective connectivity in the patients for the simple motor task suggests local network modulation contributing to enhanced long-distance effective connectivity in MS patients. This extends and generalizes previous evidence that enhancement of effective connectivity may provide an important compensatory mechanism in MS.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
UniBasel Contributors:Kappos, Ludwig
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1065-9471
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:14
Deposited On:01 Mar 2013 11:10

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