Regulatory allospecific NK cell function is differentially associated with HLA C allotypes

Zenhaeusern, G. and Gasser, O. and Hönger, G. and Durovic, B. and Stern, M. and Hess, C.. (2009) Regulatory allospecific NK cell function is differentially associated with HLA C allotypes. American journal of transplantation : official journal of the American Society of Transplant Surgeons (ASTS) and the American Society of Transplantation (AST), Vol. 9. pp. 2624-2630.

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Official URL: http://edoc.unibas.ch/dok/A6005809

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Major histocompatibility complex I (MHC I) molecules 'silence' natural killer (NK) cell activity. Conversely, NK cell activity is triggered through cells lacking expression of autologous MHC I. Unexpectedly we found that a subset of NK cells is activated rather than silenced when interacting with cells expressing normal levels of autologous MHC I. Instead of inducing an inflammatory phenotype, however, activation led to the secretion of the regulatory cytokines TGF-beta and IL-10. Importantly, in vitro models of allogeneic interactions showed that targets co-expressing HLA C1 and C2 epitopes best supported, or even enhanced, this cell-contact-mediated regulatory NK cell function. Together, these data ascribe a novel pattern of reactivity to NK cells, with potential implications both in autologous and allogeneic systems.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immunobiology (Hess C)
UniBasel Contributors:Hess, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:13
Deposited On:01 Mar 2013 11:09

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