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SPARC-like 1 (SPARCL1), a gene downregulated in non-small cell lung cancer

Isler, Silvia G.. SPARC-like 1 (SPARCL1), a gene downregulated in non-small cell lung cancer. 2004, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_6781

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Abstract

The aim of this thesis was to find out whether SPARCL1 is a tumor suppressor gene with mutation or deletion in its genomic region and to reveal the mechanism leading to its downregulation. Furthermore, we wanted to see whether SC1 mRNA is also downregulated in mouse lung tumors. Using a new anti-SPARCL1/SC1 antibody we planned to investigate the protein expression pattern in different healthy tissues as well as in tumorous tissues of humans and mice.
Advisors:Ludwig, Christian
Committee Members:Affolter, Markus and Chiquet-Ehrismann, Ruth
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik)
UniBasel Contributors:Affolter, Markus
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:6781
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:75
Language:English
Identification Number:
Last Modified:22 Jan 2018 15:50
Deposited On:13 Feb 2009 15:10

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