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Current role of stem cell transplantation in chronic myeloid leukaemia

Gratwohl, Alois and Heim, Dominik. (2009) Current role of stem cell transplantation in chronic myeloid leukaemia. Best practice & research. Clinical haematology, Vol. 22. pp. 431-443.

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Official URL: http://edoc.unibas.ch/dok/A6004340

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Abstract

Haematopoietic stem cell transplantation (HSCT) has seen considerable ups and downs in its role for patients with chronic myeloid leukaemia (CML). It has provided the first proof of the principle for cure and has confirmed the concept of successful immunotherapy of leukaemia. CML became the most frequent indication for an allogeneic HSCT worldwide. The frequency of HSCT declined rapidly when the specific BCR/ABL tyrosine kinase inhibitor (TKI) imatinib appeared. Today, a balanced view prevails. Risk assessment of both, disease risk and transplant risk, has become standard. Allogeneic HSCT remains the first-line approach for patients with CML in accelerated phase or blast crisis. It is the standard of care for patients with failed first-line therapy and a low-risk HSCT. It is the best option for all patients with failed second-line TKIs, with mutations T315I or with progressive disease. It can always be considered in situations with limited resources.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Hämatologie (Gratwohl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Hämatologie (Gratwohl)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg)
UniBasel Contributors:Gratwohl, Alois A. and Heim, Dominik A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Baillière Tindall
ISSN:1521-6926
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:45

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