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Dietary tocopherol supplementation after trabeculectomy and phacotrabeculectomy : double-blind randomized placebo-controlled trial

Goldblum, David and Meyenberg, Alexander and Mojon, Daniel and Tappeiner, Christoph and Frueh, Beatrice E.. (2009) Dietary tocopherol supplementation after trabeculectomy and phacotrabeculectomy : double-blind randomized placebo-controlled trial. Ophthalmologica, 223 (4). pp. 228-232.

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Official URL: http://edoc.unibas.ch/dok/A6005650

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Abstract

PURPOSE: The vitamin E compound alpha-tocopherol inhibits fibroblast growth in vitro. To evaluate its potential benefit in preventing failure of glaucoma filtration surgery, we prospectively investigated the outcome of filtering surgery with postoperative dietary alpha-tocopherol supplementation. PATIENTS AND METHODS: Thirty-nine patients (39 eyes) with primary open-angle glaucoma or pseudoexfoliative glaucoma were randomly assigned to two post-(phaco)-trabeculectomy treatment groups. Daily oral intake of 300 mg alpha-tocopheryl-acetate (absorbed as alpha-tocopherol in the intestine) for 2 months was compared to a placebo preparation in a double-blind trial. The follow-up time was 1 year. Success was defined as intraocular pressure (IOP) >or=18 mm Hg with no medication, no needling revision, and no subconjunctival injection. RESULTS: In the tocopherol group, the relative risk for trabeculectomy failure decreased from 1.58 at 2 weeks (p = 0.95) to 1.0 at 1 year. Success rates (67-90%) and IOP reduction (mean 39 to 53%) were statistically comparable in the two groups. Considering postoperative complications, no relevant differences were found. DISCUSSION: Trabeculectomy and phacotrabeculectomy outcome did not show any differences between alpha-tocopherol-supplemented patients and the placebo group.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
UniBasel Contributors:Goldblum, David
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Karger
ISSN:0030-3755
e-ISSN:1423-0267
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:25 Oct 2017 06:57
Deposited On:01 Feb 2013 08:45

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