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Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients

Erlic, Zoran and Rybicki, Lisa and Peczkowska, Mariola and Golcher, Henriette and Kann, Peter H. and Brauckhoff, Michael and Müssig, Karsten and Muresan, Michaela and Schäffler, Andreas and Reisch, Nicole and Schott, Matthias and Fassnacht, Martin and Opocher, Giuseppe and Klose, Silke and Fottner, Christian and Forrer, Flavio and Plöckinger, Ursula and Petersenn, Stephan and Zabolotny, Dimitry and Kollukch, Oleg and Yaremchuk, Svetlana and Januszewicz, Andrzej and Walz, Martin K. and Eng, Charis and Neumann, Hartmut P. H. and European-American Pheochromocytoma Study Group, . (2009) Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients. Clinical cancer research : a journal of clinical and translational research, Vol. 15. pp. 6378-6385.

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Official URL: http://edoc.unibas.ch/dok/A6004923

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Abstract

Six pheochromocytoma susceptibility genes causing distinct syndromes have been identified; approximately one of three of all pheochromocytoma patients carry a predisposing germline mutation. When four major genes (VHL, RET, SDHB, SDHD) are analyzed in a clinical laboratory, costs are approximately $3,400 per patient. The aim of the study is to systematically obtain a robust algorithm to identify who should be genetically tested, and to determine the order in which genes should be tested.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild)
UniBasel Contributors:Forrer, Flavio
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for Cancer Research
ISSN:1078-0432
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:45

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