Structure-selective catalytic alkylation of DNA and RNA

Tishinov, Kiril and Schmidt, Kristina and Häussinger, Daniel and Gillingham, Dennis. (2012) Structure-selective catalytic alkylation of DNA and RNA. Angewandte Chemie International Edition, 51 (48). pp. 12000-12004.

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Official URL: http://edoc.unibas.ch/dok/A6070415

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A variety of nucleic acids can be catalytically alkylated with rhodium-carbenoids generated from diazo compounds in aqueous buffer through an NH insertion process (see scheme; MES=2-(N-morpholino)ethanesulfonic acid). The method specifically targets unpaired bases such as those present in single strands, turn regions, and overhangs while leaving double-stranded sequences untouched.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Gillingham)
UniBasel Contributors:Gillingham, Dennis and Tishinov, Kiril and Häussinger, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Feb 2017 10:41
Deposited On:01 Feb 2013 08:44

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