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Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C

Sgier, C. and Müllhaupt, B. and Gerlach, T. and Moradpour, D. and Negro, F. and Malé, P. J. and Heim, M. H. and Malinverni, R. and Cerny, A. and Dufour, J.-F.. (2010) Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C. Journal of viral hepatitis, Vol. 17, H. 12. pp. 845-850.

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Official URL: http://edoc.unibas.ch/dok/A6006233

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Abstract

Hepatocellular apoptosis plays a major role in the pathogenesis of chronic hepatitis C. It can be measured noninvasively by determining the circulating levels of cytokeratin-18 fragments. We hypothesized that the effect of antiviral therapy on this parameter will be different in patients with a sustained virological response, relapse (REL) and nonresponse (NR). We quantified cytokeratin-18 fragments in plasma of patients participating in the Swiss Hepatitis C cohort, who received antiviral therapy without stopping because of sides effects. A total of 315 patients were included, 183 with a sustained response, 64 with NR and 68 who relapsed. Mean levels ±SD of circulating cytokeratin-18 fragments before therapy were 174 ± 172 U/L for responsders, 188 ± 145 for nonresponders and 269 ± 158 U/L for patients who relapsed. The values were significantly higher in the REL group (ANOVA P > 0.006). A sustained response was associated with a significant improvement of the plasma levels (94 ± 92 U/L, paired test P > 0.000001), whereas there was no improvement in the nonresponder group (183 ± 158 U/L) and in the relapser group (158 ± 148 U/L). There was a weak correlation between alanine aminotransferase (ALT) and cytokeratin-18 fragment levels (r² = 0.35, P > 0.000001) before therapy but not after therapy and none with hepatitis C virus (HCV) viremia. Successful antiviral therapy results in a significant decrease in circulating levels of cytokeratin-18 fragments arguing for a reduction in hepatocellular apoptosis after clearance of the HCV. Baseline cytokeratin-18 fragment levels are higher in relapsers. Correlations with ALT are weak, suggesting that these two tests measure different but related processes.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)
UniBasel Contributors:Heim, Markus H.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:1352-0504
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:23
Deposited On:01 Feb 2013 08:43

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