Cutting edge : IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells

Schmutz, Sandrine and Bosco, Nabil and Chappaz, Stephane and Boyman, Onur and Acha-Orbea, Hans and Ceredig, Rhodri and Rolink, Antonius G. and Finke, Daniela. (2009) Cutting edge : IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells. Journal of immunology : official journal of the American Association of Immunologists, Vol. 183. pp. 2217-2221.

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Official URL: http://edoc.unibas.ch/dok/A6006786

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During fetal life, CD4(+)CD3(-) lymphoid tissue inducer (LTi) cells are required for lymph node and Peyer's patch development in mice. In adult animals, CD4(+)CD3(-) cells are found in low numbers in lymphoid organs. Whether adult CD4(+)CD3(-) cells are LTi cells and are generated and maintained through cytokine signals has not been directly addressed. In this study we show that adult CD4(+)CD3(-) cells adoptively transferred into neonatal CXCR5(-/-) mice induced the formation of intestinal lymphoid tissues, demonstrating for the first time their bona fide LTi function. Increasing IL-7 availability in wild-type mice either by IL-7 transgene expression or treatment with IL-7/anti-IL-7 complexes increased adult LTi cell numbers through de novo generation from bone marrow cells and increased the survival and proliferation of LTi cells. Our observations demonstrate that adult CD4(+)lineage(-) cells are LTi cells and that the availability of IL-7 determines the size of the adult LTi cell pool.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Developmental Immunology (Finke)
UniBasel Contributors:Finke, Daniela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Assoc. of Immunologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:42

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