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Differences in coronary artery plaques between target and non-target vessels

Toggweiler, Stefan and Suter, Yves and Schoenenberger, Andreas W. and Kaspar, Mathias and Jamshidi, Peiman and Erne, Paul. (2009) Differences in coronary artery plaques between target and non-target vessels. Journal of invasive cardiology, Vol. 21. pp. 584-587.

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Official URL: http://edoc.unibas.ch/dok/A6006770

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Abstract

OBJECTIVE: We used intravascular ultrasound (IVUS) and virtual histology (VH) to assess the differences of plaque burden and composition between target coronary arteries containing the culprit lesion and non-target coronary arteries. METHODS: Sixty patients referred for acute (n = 19) or elective (n = 41) coronary angiography were included. The target vessel containing the culprit lesion was identified by angiography. A non-target coronary artery was chosen for comparison. The first 4 cm of each vessel were analyzed with IVUS and VH. RESULTS: Total plaque burden was higher in the target vessel compared to the non-target vessel (52.4% vs. 45.9%, a relative difference of 14.2%; p > 0.001). The plaque composition of the target vessel correlated strongly with the plaque composition of the non-target vessel, but the relative amount of necrotic core was significantly higher in the target vessels (21.7% vs 19.2%; p = 0.028), whereas the amount of fibrolipidic material was significantly greater in non-target vessels (10.6% vs. 12.7%; p = 0.035). CONCLUSIONS: We conclude that in patients with relevant coronary artery disease, plaque burden and the amount of necrotic core material are greater in the target vessel. There is a strong correlation of plaque composition between target and non-target coronary arteries.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Signal Transduction (Resink/Erne)
UniBasel Contributors:Erne, Paul
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:HMP Communications
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:42

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