CADISP-genetics : an International project searching for genetic risk factors of cervical artery dissections

Debette, S. and Metso, T. M. and Pezzini, A. and Engelter, S. T. and Leys, D. and Lyrer, P. and Metso, A. J. and Brandt, T. and Kloss, M. and Lichy, C. and Hausser, I. and Touzé, E. and Markus, H. S. and Abboud, S. and Caso, V. and Bersano, A. and Grau, A. and Altintas, A. and Amouyel, P. and Tatlisumak, T. and Dallongeville, J. and Grond-Ginsbach, C.. (2009) CADISP-genetics : an International project searching for genetic risk factors of cervical artery dissections. International journal of stroke : official journal of the International Stroke Society, Vol. 4. pp. 224-230.

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Official URL: http://edoc.unibas.ch/dok/A6006345

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BACKGROUND: Cervical artery dissection (CAD) is a frequent cause of ischemic stroke, and occasionally death, in young adults. Several lines of evidence suggest a genetic predisposition to CAD. However, previous genetic studies have been inconclusive mainly due to insufficient numbers of patients. Our hypothesis is that CAD is a multifactorial disease caused by yet largely unidentified genetic variants and environmental factors, which may interact. Our aim is to identify genetic variants associated with an increased risk of CAD and possibly gene-environment interactions. METHODS: We organized a multinational European network, Cervical Artery Dissection and Ischemic Stroke Patients (CADISP), which aims at increasing our knowledge of the pathophysiological mechanisms of this disease in a large group of patients. Within this network, we are aiming to perform a de novo genetic association analysis using both a genome-wide and a candidate gene approach. For this purpose, DNA from approximately 1100 patients with CAD, and 2000 healthy controls is being collected. In addition, detailed clinical, laboratory, diagnostic, therapeutic, and outcome data are being collected from all participants applying predefined criteria and definitions in a standardized way. We are expecting to reach the above numbers of subjects by early 2009. CONCLUSIONS: We present the strategy of a collaborative project searching for the genetic risk factors of CAD. The CADISP network will provide detailed and novel data on environmental risk factors and genetic susceptibility to CAD.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie
UniBasel Contributors:Engelter, Stefan
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:42

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