Microstructural organization of cerebellar tracts in schizophrenia

Kanaan, Richard A. A. and Borgwardt, Stefan and McGuire, Philip K. and Craig, Michael C. and Murphy, Declan G. M. and Picchioni, Marco and Shergill, Sukhwinder S. and Jones, Derek K. and Catani, Marco. (2009) Microstructural organization of cerebellar tracts in schizophrenia. Biological psychiatry : the journal of the Society of Biological Psychiatry, Vol. 66. pp. 1067-1069.

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Official URL: http://edoc.unibas.ch/dok/A6003190

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BACKGROUND: Dysconnectivity theories of schizophrenia would suggest that the connectivity of the cerebellum is impaired and that the impairment may be restricted to certain tracts. Attempts to examine the structural connectivity of the cerebellum using diffusion tensor imaging have yielded conflicting results. However, previous studies have employed region-of-interest approaches or have used small or unmatched samples, with a consequent risk of type II error. METHODS: We conducted an appropriately powered case-control study of 33 patients with schizophrenia and 33 matched healthy control subjects. We used tractography to dissect the four white matter tracts of the cerebellum and measured fractional anisotropy (FA) and mean diffusivity (MD) over each tract for each subject. RESULTS: Repeated-measures analysis of variance found that FA was lower in the schizophrenia group compared with the control group, but there were no tract-specific differences between the groups. Mean diffusivity did not differ between the groups. CONCLUSIONS: Though structural connectivity is impaired in the cerebellum, it is not local to any particular tract but appears to have a wider, possibly global, distribution. Reduced fractional anisotropy with normal MD would point to the differences being due to disordered neuronal architecture rather than disordered myelination.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt)
UniBasel Contributors:Borgwardt, Stefan
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:40

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