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Natriumphosphat enthaltende Darmreinigungsmittel - eine Gefahr für die Niere?

Russmann, S. and Szeless, Th and Bock, A. and Kullack-Ubick, G.. (2009) Natriumphosphat enthaltende Darmreinigungsmittel - eine Gefahr für die Niere? Swiss medical forum = Schweizerisches Medizin-Forum, Vol. 9. pp. 336-339.

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Official URL: http://edoc.unibas.ch/dok/A6004262

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Abstract

Bowel preparations containing Sodium phosphate –
a risk for renal damage?
- There are several well-documented cases of acute irreversible renal failure involving renal calcium phosphate deposits after the use of bowel preparations
containing sodium phosphate (e.g., Colophos®).
- Neither randomised clinical nor epidemiological studies have established an association between sodium phosphate use and renal damage in patients without preexisting renal dysfunction.
- However, it is likely that patients with preexisting renal dysfunction and other risk factors were not sufficiently represented and analysed in these studies,
and may be at increased risk of (further) renal damage through sodium phosphate.
- Recommendations for clinical practice:
1. Routine determination of renal function through GFR estimation before prescription of bowel cleansing preparations containing sodium phosphate.
2. If sodium phosphate is administered, sufficient hydration is crucial: 2 L of fluids should be consumed with each 90 ml bottle of Colophos®.
3. Sodium phosphate should not be used in patients with preexisting renal dysfunction (GFR <60 ml/min), and in those with other risk factors (heart failure, concomitant use of ACE inhibitors, angiotensin receptor blockers and diuretics, preexisting dehydration and electrolyte disorders, old age). Bowel preparations containing polyethylene glycol (e.g., Cololyt®) should be given to these patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Nephrologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Nephrologie
UniBasel Contributors:Bock, H. Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:EMH Schweizerischer Aerzte-Verlag
ISSN:1424-3784
Note:Publication type according to Uni Basel Research Database: Journal article
Language:German
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Last Modified:31 Dec 2015 10:51
Deposited On:04 Jan 2013 08:37

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