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Blood oxygenation level-dependent MRI of the skeletal muscle during ischemia in patients with peripheral arterial occlusive disease

Potthast, S. and Schulte, A. and Kos, S. and Aschwanden, M. and Bilecen, D.. (2009) Blood oxygenation level-dependent MRI of the skeletal muscle during ischemia in patients with peripheral arterial occlusive disease. RÖFO : vereinigt mit Aktuelle Radiologie : Fortschritte auf dem Gebiete der Röntgenstrahlen und der bildgebenden Verfahren : Organ der Deutschen Röntgengesellschaft ... [et al.], Vol. 181. pp. 1157-1161.

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Official URL: http://edoc.unibas.ch/dok/A6005091

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Abstract

PURPOSE: To compare calf muscle Blood Oxygenation Level-Dependent (BOLD) response during ischemia in patients suffering from peripheral arterial occlusive disease (PAOD) and age-matched non-PAOD subjects. MATERIALS AND METHODS: PAOD patients with symptoms of intermittent calf claudication and an age-matched control group underwent T 2*-weighted single-shot multi-echo planar imaging on a whole-body MR scanner at 1.5 T. The muscle BOLD signal in the calf was acquired during 60 sec of baseline and 240 sec of ischemia induced by cuff compression. T 2* time courses in four calf muscles were evaluated. RESULTS: Significant differences in the mean T 2* values were noted after 150 sec of measurement (p > 0.05). Patients with PAOD revealed a significantly reduced BOLD signal decrease compared to an age-matched control group. CONCLUSION: Potential cause for this observation may be changes in the structure and/or the metabolic turnover of the muscle in PAOD patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Medizinische Radiologie (Steinbrich)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Medizinische Radiologie (Steinbrich)
UniBasel Contributors:Bilecen, Deniz and Potthast, Silke and Kos, Sebastian
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Thieme
ISSN:0340-1618
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Jan 2013 08:38
Deposited On:04 Jan 2013 08:37

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