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Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

Dumortier, Alexis and Durham, André-Dante and Di Piazza, Matteo and Vauclair, Sophie and Koch, Ute and Ferrand, Gisèle and Ferrero, Isabel and Demehri, Shadmehr and Song, Lynda Li and Farr, Andrew G. and Leonard, Warren J. and Kopan, Raphael and Miele, Lucio and Hohl, Daniel and Finke, Daniela and Radtke, Freddy. (2010) Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS ONE, Vol. 5, H. 2 , e9258.

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Official URL: http://edoc.unibas.ch/dok/A6003937

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Abstract

The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of loss of Notch signaling after birth.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Developmental Immunology (Finke)
UniBasel Contributors:Finke, Daniela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2018 06:40
Deposited On:07 Dec 2012 13:03

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