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Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

Ehses, J. A. and Meier, D. T. and Wueest, S. and Rytka, J. and Boller, S. and Wielinga, P. Y. and Schraenen, A. and Lemaire, K. and Debray, S. and Van Lommel, L. and Pospisilik, J. A. and Tschopp, O. and Schultze, S. M. and Malipiero, U. and Esterbauer, H. and Ellingsgaard, H. and Rütti, S. and Schuit, F. C. and Lutz, T. A. and Böni-Schnetzler, M. and Konrad, D. and Donath, Marc Y.. (2010) Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet. Diabetologia, Vol. 53, no. 8. pp. 1795-1806.

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Official URL: http://edoc.unibas.ch/dok/A6006423

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Abstract

Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors that coordinate the innate inflammatory response to numerous substances, including NEFAs. Here we investigated a potential contribution of TLR2 to the metabolic dysregulation induced by high-fat diet (HFD) feeding in mice.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0012-186X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Dec 2012 13:03
Deposited On:07 Dec 2012 13:01

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