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T-cadherin loss induces an invasive phenotype in human keratinocytes and squamous cell carcinoma (SCC) cells in vitro and is associated with malignant transformation of cutaneous SCC in vivo

Pfaff, D. and Philippova, M. and Buechner, S. A. and Maslova, K. and Mathys, T. and Erne, P. and Resink, T. J.. (2010) T-cadherin loss induces an invasive phenotype in human keratinocytes and squamous cell carcinoma (SCC) cells in vitro and is associated with malignant transformation of cutaneous SCC in vivo. British journal of dermatology, Vol. 163, H. 2. pp. 353-363.

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Official URL: http://edoc.unibas.ch/dok/A6003956

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Abstract

Cadherins play important roles in controlling keratinocyte growth, differentiation and survival. Atypical glycosylphosphatidylinositol-anchored T-cadherin (T-cad) is highly expressed in the basal keratinocyte layer of skin. The role of T-cad in keratinocyte biology and pathology is unclear.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Signal Transduction (Resink/Erne)
03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB
UniBasel Contributors:Büchner, Stanislaw and Erne, Paul and Resink, Thérèse J.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lewis
ISSN:0007-0963
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 May 2014 08:34
Deposited On:07 Dec 2012 12:59

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