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Dysplastic cells in cytological cervical samples show a high incidence of chromosomal abnormalities

Song, Minghao and Ruth, Adam and Policht, Frank A. and Bubendorf, Lukas and Feichter, Georg and Kipp, Benjamin R. and Halling, Kevin C. and Sokolova, Irina A.. (2010) Dysplastic cells in cytological cervical samples show a high incidence of chromosomal abnormalities. Diagnostic cytopathology, Vol. 38, H. 1. pp. 28-33.

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Official URL: http://edoc.unibas.ch/dok/A6006735

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Abstract

Chromosomal abnormalities are frequent in most cervical cancers. Amplifications of both the 3q26 (TERC) and 8q24 (MYC) loci have been shown to be prevalent in both high-grade lesions and invasive cervical carcinoma. Most of these studies have looked at either the histological sample or at the entire cytological population of cells. We have developed a Papanicolaou (Pap) destaining method that allows for the accurate analysis of individual cells that were previously identified by cytopathology as dysplastic. The application of fluorescence in situ hybridization (FISH) was then implemented to determine the chromosomal status of the dysplastic cells in the samples and correlate the two events. Chromosomal abnormality is over a thousand times more frequent in dysplastic cells compared with their morphologically normal counterparts.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Stammzellpathologie (Bubendorf)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Stammzellpathologie (Bubendorf)
UniBasel Contributors:Bubendorf, Lukas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Liss
ISSN:8755-1039
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Dec 2012 13:03
Deposited On:07 Dec 2012 12:59

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