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European 1 : a globally important clonal complex of Mycobacterium bovis

Smith, N. H. and Berg, S. and Dale, J. and Allen, A. and Rodriguez, S. and Romero, B. and Matos, F. and Ghebremichael, S. and Karoui, C. and Donati, C. and Machado, A. D. and Mucavele, C. and Kazwala, R. R. and Hilty, M. and Cadmus, S. and Ngandolo, B. N. and Habtamu, M. and Oloya, J. and Muller, A. and Milian-Suazo F., and Andrievskaia, O. and Projahn, M. and Barandiaran, S. and Macias, A. and Muller, B. and Zanini, M. S. and Ikuta, C. Y. and Rodriguez, C. A. and Pinheiro, S. R. and Figueroa, A. and Cho, S. N. and Mosavari, N. and Chuang, P. C. and Jou, R. and Zinsstag, J. and van Soolingen D., and Costello, E. and Aseffa, A. and Proano-Perez F., and Portaels, F. and Rigouts, L. and Cataldi, A. A. and Collins, D. M. and Boschiroli, M. L. and Hewinson, R. G. and Neto, J. S. and Surujballi, O. and Tadyon, K. and Botelho, A. and Zarraga, A. M. and Buller, N. and Skuce, R. and Michel, A. and Aranaz, A. and Kallenius, G. and Niemann, S. and Boniotti, M. B. and van Helden P. D., and Harris, B. and Zumarraga, M. J. and Kremer, K. and Gordon, S. V. and Jeon, B. Y.. (2011) European 1 : a globally important clonal complex of Mycobacterium bovis. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics and infectious diseases (MEEGID), Vol. 11, H. 6. pp. 1340-1351.

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Official URL: http://edoc.unibas.ch/dok/A6002192

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Abstract

We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health > One Health (Zinsstag)
UniBasel Contributors:Zinsstag, Jakob Z
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:1567-1348
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:21

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